Given that there's no information on Brian Shaffer since 2006, I figure a mention can't hurt.
From the find Brian Shaffer web site:
On the night of Friday, March 31st 2006; Brian Shaffer, a 27 year old 2nd year medical student at OSU went out with friends to have a few drinks and celebrate the beginning of Spring break 2006; it was his 'time out with the guys'. At around 9:30pm, the men headed to the Ugly Tuna Saloona, a bar located near the OSU campus. At 9:56pm, Brian called Alexis -his girlfriend- who at the time was visiting her family in Toledo, OH. He told her he loved her and that he would see her when she came back to Columbus; the two had planned on taking a vacation to Miami and were scheduled to leave for Florida on Monday, April 3rd. Shortly after talking to Alexis, Brian and his friend walked down to the Arena District in Columbus, OH; they stopped at the North Short Tavern and then went to Brother's, where they met with other friends. One of the friends drove them back to the Ugly Tuna Saloona, where they are seen in the surveillance tape at 1:15 am. The next time Brian is seen on cameras, he was outside of the Ugly Tuna, at the top of the escalator, talking with two girls; he appears to say 'bye' and turns towards the bar, he then disappears from the camera's view and has not been seen since.
There's also a PDF of the flyer:
Obviously, if any of you dear readers has some pertinent information to share on what happened to Brian Shaffer call 1-877-645-TIPS (8477). I understand they permit callers to remain anonymous, although how that works with the reward I couldn't tell you.